What is the difference between the Collagenase HA and Collagenase MA products?

Collagenase HA and MA differ only in the amount of truncated class 1 collagenase present. Both are 60%:40% blends of highly purified class 1 (C1) and class 2 collagenase (C2), respectively. The Collagenase MA will have a lower CDA specific activity relative to the HA product, because a portion of the C1 protein in the MA product has lost a collagen binding domain whereas HA is comprised of only intact C1. The two products have comparable Wunsch specific activities.