VitaCyteUnravelling Cell Isolation
VitaCyte manufactures and supplies GMP Grade purified-defined Clostridium histolyticum collagenase and protease enzymes to researchers, commercial cell suppliers, and institutions that manufacture cells as therapeutic agents. VitaCyte’s capabilities to custom manufacture products enables collaboration with companies who use enzymes for commercial applications.
Research
Cell Suppliers
Cell Therapy
Our ProductsPurified Cell and Tissue Dissociation Enzymes
Highly Purified
Lot to Lot Consistent
Best Performing Enzymes
Ability to Design Mixtures for Specific Applications
Ability to Customize Product to Meet Your Needs
Purified-Defined EnzymesWhat does it mean?
Collagenase suppliers can be divided into three categories:
Traditional Crude or Enriched Collagenase
Purified Collagenase
Purified-Defined Collagenase
Our StoryHow VitaCyte Began
VitaCyte’s co-founders, Bob McCarthy and Francis Dwulet, were key contributors to the development of the first commercial, purified collagenase-protease enzyme mixture used to prepare cells for subsequent transplantation. This improved tissue dissociation enzyme reagent contributed to success of the “Edmonton Protocol,” the first report of successful treatment of adult patients with Type 1 Diabetes where 7 of 7 patients were “insulin independent” one year after islet transplantation. Prior to the introduction of this purified enzyme reagent, most laboratories performing this clinical research procedure were spending significant amounts of time qualifying collagenase lots for their effectiveness to isolate human islets. Once a lot was selected, the lot qualification procedure was repeated within a year, often because of the instability of the enzymes on storage.
ResourcesAll things cell isolation
Short Videos on the Origin of Cells in Adipose Tissue
Robert McCarthy In an earlier commentary, I provided my perspective on the comprehensive review Stu Williams gave in a VitaCyte-sponsored webinar, “Characterization and Therapeutic Use of Adipose Derived Cells: Some Inconvenient Truths,” presented on March 6, 2025....
Human-Relevant Vascularized Tissue Models
Thursday, June 19, 2025 | 11 AM ETPresented byJames B. Hoying, PhDThe need for more informative and predictive cell and tissue models of human disease is driving technological innovations that leverage tissue biology concepts. This webinar will explore some of these...
Cell Recovery Using Clostridium histolyticum Enzyme Products
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For questions regarding enzyme useage, regardless if they are directly related to VitaCyte’s products, Customer Service is excellent. People at the company are eager to share their valuable experience and opinions on how best to perform procedures from donors of various species.
Latest NewsAll things cell isolation
IPITA 2025
AttendingVitaCyte will attend the 20th World Congress of the International Pancreas and Islet Transplant Association 2025. Drew Breite along with a representative from our European distributor, Pelobiotech, will be at this meeting to learn about new developments in...
WFIRM Regenerative Medicine Essentials (RME) 2025
We are proud to partner with WFIRM's Regenerative Medicine Essentials (RME) 2025. 12th Annual RME Course: The Foundations into the FutureJune 10-12, 2025 | Innovation Quarter, Winston-Salem, NC, USAAttendingRobert McCarthyPresident & Co-FounderExhibiting Come...
Employee Spotlight
April - June 2025 We like to celebrate every milestone of our employees who make VitaCyte possible.happy birthdayFrancis DwuletBob McCarthyvitacyte mothersDonna SkinnerAmber McDonoughJessica Helwegvitacyte fathersBob McCarthyFrancis DwuletMike GreenMatt SkinnerDan...