Webinar: Challenges of Recovering Islets from Chronic Pancreatitis Patients

Presented by Gopalakrishnan Loganathan, Ph.D.
University of Louisville

Islet yield is the critical factor for the success of autologous islet transplantation. The higher the islet yield, the higher probability of the recipient will have an easier time managing iatrogenic diabetes created by this procedure.
Recovery of islets from pancreas recovered as part of total pancreatectomy, islet auto-transplant procedure (TP-IAT) is challenging since chronic inflammation results in extensive fibrosis with the pancreatic ducts often blocked. The challenge of the standard islet isolation procedure must be modified to increase islet yields from these diseased organs.

The webinar will:
– Review the histopathology found in the pancreas recovered from chronic pancreatitis patients
– Outline the changes that a leading TP-IAT center adopted to increase islet yields
– Present an “outside the box” approach to consider if all else fails

Lab Armor Beads

Many of you asked about the metal beads that are used in place of an ice-water bath. Here is where you can find them.

Reference List

Here is the webinar reference list you can download.

About Gopalakrishnan

Gopalakrishnan Loganathan, Ph.D.​​​​​​​​​​​
​​University of Louisville

I have more than ten years of basic and translational research experience, focusing on mammalian islet isolation and transplantation. In 2007, I joined the islet isolation group at the Schulze Diabetes Institute at the University of Minnesota (UMN). I later worked at the University of Louisville and Koligo Therapeutics to isolate human islets. I have actively participated in or performed more than 500 human islet isolation procedures for clinical auto- or allo- islet transplantations. At UMN, I also performed porcine and non-human primate islet isolations for preclinical research. Since 2011, I was the primary or co-author of 26 publications focused on using mammalian islets for research or clinical applications.