VitaCyteUnravelling Cell Isolation
VitaCyte manufactures and supplies GMP Grade purified-defined Clostridium histolyticum collagenase and protease enzymes to researchers, commercial cell suppliers, and institutions that manufacture cells as therapeutic agents. VitaCyte’s capabilities to custom manufacture products enables collaboration with companies who use enzymes for commercial applications.
Research
Cell Suppliers
Cell Therapy
Our ProductsPurified Cell and Tissue Dissociation Enzymes
Highly Purified
Lot to Lot Consistent
Best Performing Enzymes
Ability to Design Mixtures for Specific Applications
Ability to Customize Product to Meet Your Needs
Purified-Defined EnzymesWhat does it mean?
Collagenase suppliers can be divided into three categories:
Traditional Crude or Enriched Collagenase
Purified Collagenase
Purified-Defined Collagenase
Our StoryHow VitaCyte Began
VitaCyte’s co-founders, Bob McCarthy and Francis Dwulet, were key contributors to the development of the first commercial, purified collagenase-protease enzyme mixture used to prepare cells for subsequent transplantation. This improved tissue dissociation enzyme reagent contributed to success of the “Edmonton Protocol,” the first report of successful treatment of adult patients with Type 1 Diabetes where 7 of 7 patients were “insulin independent” one year after islet transplantation. Prior to the introduction of this purified enzyme reagent, most laboratories performing this clinical research procedure were spending significant amounts of time qualifying collagenase lots for their effectiveness to isolate human islets. Once a lot was selected, the lot qualification procedure was repeated within a year, often because of the instability of the enzymes on storage.
ResourcesAll things cell isolation
A Rational Design Method to Prepare Purified Collagenase Protease Mixtures
Robert McCarthy “The most damaging phrase in the language is ‘We’ve always done it this way.’” Grace Hopper, US Navy Rear Admiral, Computer Scientist, developed COBOL Updates to an Earlier Blog Post An earlier blog post, “Are you tired of lot qualification, try...
Collagenase Color: What Does it Tell You About Product Quality?
“Science progresses best when observations force us to alter our preconceptions." Vera Rubin, Astronomer What causes the color of traditional collagenase products? Traditional crude and enriched collagenase products can range in color from a light tan to dark brown....
Isolation of Cells from Fat
Thursday, September 26, 2024 | 11 AM ETPresented byStuart K. Williams, PhD In March 1964, Martin Rodbell reported that rat adipocytes isolated by digesting minced parametrial fat (fat around the uterus) using collagenase responded to externally delivered hormones....
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For questions regarding enzyme useage, regardless if they are directly related to VitaCyte’s products, Customer Service is excellent. People at the company are eager to share their valuable experience and opinions on how best to perform procedures from donors of various species.
Latest NewsAll things cell isolation
Grim Reaper on the Plate Reader
Something Happened Fri, September 13, 2024 We came in to find bloody prints on the back storage door. Everyone is accounted for so we're not sure who's it is.We put tape up until we can figure out what happened.Wed, September 18, 2024 We're still not sure what...
National Liver Awareness Month
October is National Liver Awareness Month For the whole month of October, there will be a Liver Man Squishy Toy added to your orders. Googly eyes are included but not assembled. Happy Building! USA only. As supplies last.
ISCT 2024
We are proud to sponsor International Society for Cell & Gene Therapy 2024.May 28 – June 1, 2024 | Vancouver, CanadaAttendingRobert McCarthyPresident & Co-FounderAaron CraigDirector of Quality AssuranceAndrew BreiteAssociate Dir of QA & Customer Service...