VitaCyteUnravelling Cell Isolation
VitaCyte manufactures and supplies GMP Grade purified-defined Clostridium histolyticum collagenase and protease enzymes to researchers, commercial cell suppliers, and institutions that manufacture cells as therapeutic agents. VitaCyte’s capabilities to custom manufacture products enables collaboration with companies who use enzymes for commercial applications.
Research
Cell Suppliers
Cell Therapy
Our ProductsPurified Cell and Tissue Dissociation Enzymes
Highly Purified
Lot to Lot Consistent
Best Performing Enzymes
Ability to Design Mixtures for Specific Applications
Ability to Customize Product to Meet Your Needs
Purified-Defined EnzymesWhat does it mean?
Collagenase suppliers can be divided into three categories:
Traditional Crude or Enriched Collagenase
Purified Collagenase
Purified-Defined Collagenase
Our StoryHow VitaCyte Began
VitaCyte’s co-founders, Bob McCarthy and Francis Dwulet, were key contributors to the development of the first commercial, purified collagenase-protease enzyme mixture used to prepare cells for subsequent transplantation. This improved tissue dissociation enzyme reagent contributed to success of the “Edmonton Protocol,” the first report of successful treatment of adult patients with Type 1 Diabetes where 7 of 7 patients were “insulin independent” one year after islet transplantation. Prior to the introduction of this purified enzyme reagent, most laboratories performing this clinical research procedure were spending significant amounts of time qualifying collagenase lots for their effectiveness to isolate human islets. Once a lot was selected, the lot qualification procedure was repeated within a year, often because of the instability of the enzymes on storage.
ResourcesAll things cell isolation
Clostridium histolyticum Collagenases
Thursday, November 21, 2024 | 11 AM ETPresented byBob McCarthy C. histolyticum collagenases have been used in the early 1960s for cell isolation, but most users have a limited understanding of how these enzymes dissociate tissue. The webinar will review an improved...
Published Standards for Ancillary Materials
Andrew G. Breite Two published Standards on ancillary materials (AMs) are the US Pharmacopeia (USP) <1043> and ISO 20399 International Standard. The ISO standard defines AMs as "materials that come in contact with the cellular therapeutic product during cell...
Why the Adoption of Ancillary Material Standards is Important for Cell Therapy
Bob McCarthy Windermere's "Buying Hierarchy" model categorizes the life cycle of a product into four categories: functionality, reliability, convenience, and price.(1) At the product launch, the customer asks, "Is it doing what it is supposed to do?"...
Get Updates
Get updates on what’s new, important changes, upcoming webinars and more!
For questions regarding enzyme useage, regardless if they are directly related to VitaCyte’s products, Customer Service is excellent. People at the company are eager to share their valuable experience and opinions on how best to perform procedures from donors of various species.
Latest NewsAll things cell isolation
New Product Flip Caps
Some products will now be manufactured with plastic flip cap tear-off seal enclosures. Previously, they were sealed with an aluminum crimp. This new cap will be easier and more convienent to open and deal with in an aseptic environment. Flip Cap Removal StepsImpacted...
Advanced Therapies USA 2024
ADVANCING CELL AND GENE THERAPIESNovember 12-13, 2024 | Pennsylvania Convention Center, Philadelphia, USAWe will be attending Advanced Therapies USA 2024. If you would like to meet, contact us using the meeting networking app! We would love to hear from...
Grim Reaper on the Plate Reader
Something Happened Fri, September 13, 2024 We came in to find bloody prints on the back storage door. Everyone is accounted for so we're not sure who's it is.We put tape up until we can figure out what happened.Wed, September 18, 2024 We're still not sure what...